Histopathological study of breast cancer in Libyan Patients in eastern region between years (2015 to 2018)
Is secondary sexual organ for females and source of nutrition for infants. The breasts consist of mammary glands and associated skin and connective tissues. The mammary glands are modified sweat glands in the superficial fascia on the anterior thoracic wall between ribs II and VI and overlie the pectoralis major muscle (Figure1.1).1,2 The breasts are made up of fat, supportive (connective) tissue and glandular tissue that contain lobes. The lobes (milk glands) are where milk is produced These are connected to the nipple by a network of milk ducts. It’s common for woman’s breasts to be adifferent size or shape from each other. They change throughout a woman’s life and often feel different at different times in the month because of hormonal changes. For example, just before a period they may feel lumpy. As a woman gets older, her breasts may become smaller and feel softer Under the skin, an area of breast tissue extends into the armpit (axilla) The armpits also contain a collection of lymph nodes (glands), which are part of the lymphatic system. There are also lymph nodes just beside the breast bone and behind the collar bones. The lymph nodes throughout the body are connected by a network of tiny lymphatic tubes (ducts)
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As cancer comes the first cause of death, breast cancer is the most common cancer worldwide, and this research is done to look into the causes and main factors behind this disease. The main aim of this study is to determine the characteristic of breast cancer in female Libyan patient in eastern part of Libya through analysis of several clincopathological features including histopathological type, grade and stage of the disease and to correlate these features and their immunophenotypical profile with other clinical data to better understand the biological behavior of breast cancer. To phonotypical characterize breast cancer cases according to ER, PR and Her2 status. Data of 800 cases of breast cancer were collected from archive of oncology department in Benghazi medical center. Most cases were aged between (40-50) years, most cases were grade II and stage III. For the immunohistochemical data results; nearly two-third of the cases were ER and PR positive. We also concluded that there was a significant correlation between the grade of the cancer and metastasis, as well as a significant correlation between grade and stage. Further study including large number of cases with complete histopathological and clincopathological data as well as genomic characterization are recommended to better understand the behavior and prognostic indicator of breast cancer
