Paget’s Disease & Risk Of Spinal Stenosis

Mohamed Belrasali, Talal (2019)

Typical vertebrae are a vertebral body, a vertebral spine, and seven processes. As the column goes down, the vertebral bodies increase in size. The vertebral body consists of a trabecular bone containing the red marrow, surrounded by a thin layer of compact bone from the outside. The arch, together with the back side of the body, forms the vertebral (spinal) canal containing the spinal cord. Paget's disease of bone (PDB) is the second most common type of bone disease after osteoporosis. It is a disorder of the bone remodeling process due to an increase in osteoblastic and osteoclastic activity, that lead to resorb old bone and forms deformed, enlarged, and fragile new bones. There are factors that can increase your risk to get Paget’s disease like Age (>40), sex and family history, and one of the complications of Paget’s disease is spinal stenosis.


Introduction: Paget's bone disease interferes with the usual recycling process in your body, in which new bone tissue is gradually replacing old bone tissue. Over time, the disease can cause the bones affected to become fragile and disfigured. Most commonly Paget's bone disease occurs in the pelvis, skull, spine, and neck. Materials and Methods: Of the 754 cases, 101 cases were of monostotic or polyostotic spine involvement. There were 29 cases of PDB in the spinal cord (16 males; 13 females) available for histological and histomorphometric analysis. Results: The most common PDB manifestation site was the lumbar spine (62.2 %), followed by the thoracic spine (29.6 %). The cervical spine was involved in 8.2 % of patients. Conclusion: In brief, the lumbar stenosis is the most common site in spinal stenosis

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