Relationship of Anti-Thyroid Peroxidase Antibody and Thyroid Function Test

Abstract

Background: Anti-thyroid peroxidase antibodies (anti-TPO antibody) attack thyroid peroxidase enzyme that involved in the synthesis of thyroid hormones, named thyroid autoimmune disease leads to hypothyroidism or hyperthyroidism. Objective: assess the relationship between anti-TPO antibody and thyroid function test (T4, T3, and TSH) in thyroid patients. Methods: The first study: In 2425 people suspected of thyroid disease, referred to Yazd Central Medical Laboratory by physicians for 2 years, and anti-TPO antibody, T3, T4, and TSH concentrations were measured. The second study: conducted in 160 patients who demonstrated abnormal thyroid function tests were performed at Grand City Clinic, Hospital Services, and Kantipur dental college for 18 months since Baisakh 2072. Results: The first study: 2135 patients (88.04%) were female and 290 (11.96%) were male. The levels T3, T4, and TSH in individuals with normal and elevated anti-TPO antibody titers were significantly different (P <0.0001). A correlation was detected between TSH and T4 levels and an abnormal anti-TPO antibody (P = 0.002). The second study: 126 patients (78.8%) were female and 34 (21.2%) were male. anti-TPO antibody test showed positive in 102/160 (63.8%) cases. Conclusion: The result confirms the relationship between anti-TPO antibody and thyroid function testing, which negatively affects thyroid function