Polycystic ovary syndrome and Insulin Resistance
Polycystic ovary syndrome (PCOS) is the most common, although the least understood cause of androgenic excess in premenopausal women, initially described 1935 and is also known as Stein- Leventhal syndrome. It is a multisystem endocrinopathy. Including menstrual dysfunction, infertility, obesity, acne, hirsutism, acanthosis nigricans and metabolic disorder. POCS effect 4-6% of women incidents is fast increasing due to change in lifestyle and stress. A large proportion of women with PCOS are suffering from insulin resistance, they have abnormal insulin activity which lead to risk of diabetes. Insulin stimulated glucose utilization are significantly decreased in PCOS. Hyperinsulinemia seems to play a major role in the pathogenesis of hyperandrogenism of PCOS. Hyperinsulinemia stimulates androgen secretion by the ovarian theca, excess growth of basal cells of the skin resulting in acanthosis nigricans, and abnormal hepatic and peripheral lipid metabolism. (1)
Other
Polycystic ovary syndrome (PCOS) is an imbalance of the female sex hormones also is one of the most common metabolic and reproductive disorders among women of reproductive age, associated with menstrual dysfunction and androgen excess which significantly impacts their quality of life. They may be at increased risk of multiple morbidities including obesity, type2 diabetes mellitus, infertility and cardiovascular disease. Insulin resistance (IR) is characterized by impaired glucose response to specific amount of insulin. Increasing interest in research on the mechanisms and significance of the relationship between insulin resistance and ovarian syndrome have both increased rapidly over the past 10 years. This report will review all of the risk factor and relationship between insulin resistance and ovarian syndrome but will focus primarily on the polycystic ovary syndrome (PCOS), which is the most common disorder in which these abnormalities occur together. It will also discuss the pathogenesis of polycystic ovary syndrome and its relationship to insulin resistance
