Dyslipidemia and Risk of Cardiovascular Disease
Dyslipidemia (or dyslipoproteinemia) : refers to abnormal concentrations of serum lipoproteins. it is estimated that nearly half of the U.S population has some form of dyslipidemia, especially among white and Asian populations. dyslipidemia means An increased serum concentration of low density lipoprotein (LDL) and low levels of high density lipoprotein cholesterol (HDL- C) . LDL is responsible for the delivery of cholesterol to the tissues. so the serum levels of LDL are normaly controlled by hepatic receptors for LDL that bind LDL and limit liver synthesis of this lipoprotein, HDL is responsible for "reverse cholesterol transport" which returns excess cholesterol from the tissues to the liver, where it binds to hepatic receptors (including the LDL receptor) and is processed and eliminated as bile or converted to cholesterol – containing steroids.
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Background: Dyslipidemia (or dyslipoproteinemia) : refers to abnormal concentrations of serum lipoproteins, means An increased serum concentration of low density lipoprotein (LDL) and low levels of high density lipoprotein cholesterol (HDL- C) . objectives: describe the role of high density lipoprotein and low density lipoprotein in the development of cardiovascular disease. method: In 2006, the Lithuanian High Cardiovascular Risk Primary Prevention Program was initiated in Lithuania to recognize patients at high risk of cardiovascular disease. The research recruited men between 40 and 50 years of age and women between 50 and 65 years, 83,376 patients was taken for analysis divided into two group extream dyslipidemia group and control group . Result: A total of 83,376 patients have been analyzed, from 2009 to 2015. The study found that people with extreme dyslipidemia were twice as likely as those in the control group to have three or more risk factors. conclusion: High level of LDL and low level of HDL can lead to atherosclerosis and many cardiovascular diseases .
