CORRELATION BETWEEN RENIN ANGIOTENSIN ALDOSTERON SYSTEM AND CARDIO VSASCULAR DISEASES

Abstract

Hypohydration, defined as a state of low body water, increases thirst sensations , (1) then force renin–angiotensin–aldosterone system (RAAS) which is a complex system that plays an important role in maintaining haemodynamic stability in the human body through regulation of arterial blood pressure, water and electrolyte balance. (3) RAAS has been implicated with the pathophysiology of various cardiovascular disorders including hypertension, acute myocardial infarction (AMI), congestive heart failure (CHF) reduced ejection fraction (REF) and stroke. Here, we review the role of active renin, a crucial, upstream enzymatic regulator of the RAAS, as a prognostic and diagnostic plasma biomarker of heart failure with reduced ejection fraction (HFrEF) progression , Clinical and experimental studies indicate that plasma renin activity is elevated with HFrEF . Modulation of renin activity in experimental HF significantly reduces edema formation and the progression of systolic dysfunction and improves survival. Thus, specific assessment and targeting of elevated renin activity may enhance diagnostic and therapeutic precision to improve outcomes in appropriate patients with HFrEF. (2)