Publications

Immunoglobulin Isotypes, C3 -C4 Complement Components, Absolute Eosinophils and Allergen Specific IgE as Biomarkers Correlated to Preschool Wheeze Children

2022-01-27T11:11:25Z

Immunoglobulin Isotypes, C3 -C4 Complement Components, Absolute Eosinophils and Allergen Specific IgE as Biomarkers Correlated to Preschool Wheeze Children "Mohamed El-jwhri , Rashad Shawgi , Abdulla Elmansoury and Ibtisam Kaziri" Wheeze chest is a common problem among preschool children, and represents a common disorder characterized by airways obstruction. Almost half of children manifest wheeze chest symptoms before the age of six. Their parents report at least one attack within this period. This study aimed to assess the relationship between the immunoglobulin (IgA, IgM, IgG, and IgE), complement, and the level of eosinophils with children’s wheeze chest. Moreover, the level of IgE with the numbers of the attacks per year, age, family history, and eosinophilic count. A total number of a randomized (n=73) preschool children were involved in this study, divided into 2 groups, (n=52) patients with recurrent wheezy chest attacks and (n=21) controls. Samples were analyzed for immunoglobulin isotypes; complement C3, C4, Eosinophils, and specific IgE allergen test. Number of attacks were strongly correlated with IgE with a P-value of (P=0.001), as well as the manifestation with a P-value of (P=0.002), while age was weakly correlated with IgE with a P-value of (P=0.005). The other variables in this study were found to be insignificant, correlating with IgE. Regarding specific allergens, 20 different types were evaluated in patients who had elevated levels of IgE, and the findings were that all patients were not only allergic to 1 type but unlikely to many. Most definitely the majority of the cases shared Dermatophagoides Peter (8 patients) and Dermatophagoidesf ariaeni (7 patients) allergens and so the list goes descending in the number with 2 allergens were not found, Cladosporium herbarum and Penicillium notatum.

Ameliorative Effects of the Aqueous Extract of Allium porrum (Wild Leek) against Cisplatin-Induced Nephrotoxicity in Rabbits

2022-01-27T11:11:14Z

Ameliorative Effects of the Aqueous Extract of Allium porrum (Wild Leek) against Cisplatin-Induced Nephrotoxicity in Rabbits "HS Mohammed MHS Ahmida MF Madi A A Abdel-Gayoum" The aim of the present study was to investigate the nephroprotective, hypolipidemic, and hypoglycemic effects of Allium porrum (leek) in rabbits with cisplatin nephrotoxicity. Forty adult male New Zealand rabbits were divided randomly into four groups (ten rabbits in each group) as follows: Group I: (negative control) (C) received an oral daily dose of distilled water for 15 successive days. Groups II: (Leek) (L) received an oral daily dose of aqueous leek extract (500mg/kg/day) for 15 successive days. Group III: (positive control) [cisplatin (CP)] received an oral daily dose of distilled water for 15 successive days, and subsequently administered a single dose of Cisplatin (3.5mg/kg/day) by intraperitoneal injection from day 10 for five days. Groups IV: (Leek and Cisplatin) (LCP) received an oral daily dose of aqueous leek extract (500 mg/kg/day) for 15 successive days with subsequently administered single intraperitoneal dose of cisplatin (3.5 mg/kg/day) from day 10 for five days in association with aqueous leek extract. All animals were fasted overnight then sacrificed. Serum urea, creatinine, glucose, lipids, renal histology, tissues glutathione, lipid peroxidation (thiobarbituric acid reactive substance), catalase, and superoxide dismutase were measured. cisplatin intoxication exhibited significant (P˂0.001) elevations in serum creatinine and urea with marked renal tubular injury. Whereas, treatment of aqueous leek extract prior to cisplatin intoxication significantly caused (P˂0.001) reductions of serum creatinine and urea levels with the moderation of renal histology. Cisplatin intoxication also showed significant (P˂0.01) reductions in renal glutathione and activities of catalase and superoxide dismutase and increased lipid peroxidation accompanied with increases in serum glucose, total cholesterol, triglycerides, low-density lipoproteins cholesterol, very low-density lipoproteins cholesterol, and decreased high-density lipoproteins cholesterol compared to controls. However, administration of aqueous leek extract prior to cisplatin intoxication showed significantly (P<0.001) elevated glutathione and activities of superoxide dismutase and catalase and a significant reduction in thiobarbituric acid reactive substance, reductions in glucose, triglycerides, low-density lipoproteins cholesterol, very low-density lipoproteins cholesterol and increased high-density lipoproteins cholesterol. Cisplatin treatment impaired the kidney function of rabbits with marked renal injury. This was accompanied by increased cortical lipid peroxidation and a reduced antioxidant system. Cisplatin also induced dyslipidemia and hyperglycemia. All deranged parameters were reversed by co-administration of the leek extract.

Comparison between the different Artificial Neural Network(ANN) accuracy in diagnosis of asthm

2022-01-27T11:11:02Z

Comparison between the different Artificial Neural Network(ANN) accuracy in diagnosis of asthm Hanein Omar, Dr. Mohamed Basma. F.Idris Abstract: Asthma is a chronic disease that is caused by inflammation of airways. Diagnosis, predication and classification of asthmatic are one of the major attractive areas of research for decades by using different and recent techniques, however the main problem of asthma is misdiagnosis. This paper simplifiesand compare between different Artificial Neural Network techniques used to solve this problem by using different algorithms to getting a high level of accuracy in diagnosis, prediction, and classification of asthma like: (data mining algorithms, machine learning algorithms, deep machine learning algorithms), depending and passing through three stages: data acquisition, feature extracting, data classification. According to the comparison of different techniques the high accuracy achieved by ANN was (98.85%), and the low accuracy of it was (80%), despite of the accuracy achieved by Support Vector Machine (SVM) was (86%) when used Mel Frequency Cepstral Coefficient MFCC for feature extraction, while the accuracy was (99.34%) when used Relief for extracting feature. Based in our comparison we recommend that if the researchers used the same techniques they should to return to previous studies it to get high accuracy

Basic Knowledge, Attitude, and Practice of Middle East and North African Populations Toward COVID-19

2022-01-27T11:09:32Z

Basic Knowledge, Attitude, and Practice of Middle East and North African Populations Toward COVID-19 "Hisham N Atayb, Taher Emahbes , Annour Bechir Ahmat, Mogahid M. Elhassan, and Wael K Al-Delaimy " Mariam Abbas Ibrahim , Alaa AbouElfetouh , Khalid Rahamtalla Khedir Genawi , Rashad Shawgi Jaweesh , Fatma S Dabbous,Zouhour Ouanes, Nadia El Kadmiri, Iman AMRANI , Manel Ben Fredj , Mohammed M. Mehanna , Sanaa Abujilban, Objective: This study aimed to assess the basic knowledge, attitude, and practice among people from nine Middle Eastern and North African countries about COVID-19 symptoms, modes of transmission, acceptance of recovered patients, and practice of some basic preventive measures.