Correlation between treatment of diabetes mellitus and development cancer
Diabetes Mellitus : (glucose) levels are abnormally high because the body does not produce enough insulin to meet its needs. Urination and thirst are increased, and people may lose weight even if they are not trying to. Diabetes damages the nerves and causes problems with sensation,Type one diabetes: characterized by an absolute deficiency of insulin secretion caused by pancreatic beta cells destruction Cancer : the uncontrolled of abnormal cells in the body Pathogeneses: Mutation inactivates tumor suppressor gene <<< cells proliferate <<< mutation inactivates DNA repair gene <<< mutation of proto-oncogene <<< mutation inactivates several more tumor suppressor genes <<< cancer Main factor causes cancer: Diabetes (primarily type 2) is associated with increased risk for some cancers (liver, pancreas, endometrium, colon and rectum, breast, bladder) Overweight, Obesity, and Weight Change,dite, Physical Activity (1) The association between cancer and diabetes has been investigated extensively and most, but not all studies, found that DM is associated with an increased risk of several types of cancer. Most published data, however, requires reinterpretation because DM is not a single disease, but rather a group of metabolic disorders characterized by hyperglycemia.
Other
Diabetes and cancer are two heterogeneous, multifactorial, severe, and chronic diseases. Because of their frequency, reciprocal influences – even minor influences – may have a major impact. Epidemiological studies clearly indicate that the risk of several types of cancer (including pancreas, liver, breast, colorectal, urinary tract, and female reproductive organs) is increased in diabetic patients Mortality is also moderately increased. Several confounding factors, having general or sitespecific relevance, make it difficult to accurately assess cancer risk in diabetic patients. These factors include diabetes duration, varying levels of metabolic control, different drugs used for therapy, and the possible presence of chronic complications... While anti-diabetic drugs have a minor influence on cancer risk (except the metformin that apparently reduces the risk), umerous studies have identified an increased risk of cancer in type 2 diabetes.
