Correlation between treatment of diabetes mellitus and development cancer

Abstract

Diabetes and cancer are two heterogeneous, multifactorial, severe, and chronic diseases. Because of their frequency, reciprocal influences – even minor influences – may have a major impact. Epidemiological studies clearly indicate that the risk of several types of cancer (including pancreas, liver, breast, colorectal, urinary tract, and female reproductive organs) is increased in diabetic patients Mortality is also moderately increased. Several confounding factors, having general or sitespecific relevance, make it difficult to accurately assess cancer risk in diabetic patients. These factors include diabetes duration, varying levels of metabolic control, different drugs used for therapy, and the possible presence of chronic complications... While anti-diabetic drugs have a minor influence on cancer risk (except the metformin that apparently reduces the risk), umerous studies have identified an increased risk of cancer in type 2 diabetes.